Condensation of Prometaphase Chromosomes
REACTOME PATHWAYThe Condensation of Prometaphase Chromosomes pathway (Reactome ID: R-HSA-2514853) involves 6 genes and is affected by 25 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Condensation of Prometaphase Chromosomes
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 2 | chrysin | — | 300 |
| 3 | fisetin | — | 78 |
| 4 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 5 | kenpaullone | — | 8 |
| 6 | alsterpaullone | — | 12 |
| 7 | Quercetin | — | 300 |
| 8 | indirubin | — | 300 |
| 9 | Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as | — | 300 |
| 10 | Kaempferols | — | 300 |
| 11 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 12 | Vanillic Acid | — | 300 |
| 13 | ly294002 | — | 11 |
| 14 | sp600125 | — | 117 |
| 15 | Clofibrate | — | 299 |
| 16 | Fenofibrate | — | 297 |
| 17 | Sertraline | — | 1,000 |
| 18 | Cinnarizine | — | 299 |
| 19 | Clotrimazole | — | 296 |
| 20 | Rotenone | — | 300 |
| 21 | Sorafenib | — | 300 |
| 22 | Dichlororibofuranosylbenzimidazole | — | 26 |
| 23 | Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid. | — | 300 |
| 24 | pictilisib | — | 25 |
| 25 | Axitinib | — | 298 |
About the Condensation of Prometaphase Chromosomes Pathway
The Condensation of Prometaphase Chromosomes pathway is catalogued in Reactome (ID: R-HSA-2514853) and involves 6 genes. In the BiohacksAI corpus, 25 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNB1, CCNB2, CDK1, CSNK2A1, CSNK2A2.