IRF3-mediated induction of type I IFN
REACTOME PATHWAYThe IRF3-mediated induction of type I IFN pathway (Reactome ID: R-HSA-3270619) involves 2 genes and is affected by 4 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting IRF3-mediated induction of type I IFN
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | amlexanox | — | 96 |
| 2 | Axitinib | — | 298 |
| 3 | Crizotinib | — | 298 |
| 4 | Wortmannin | — | 300 |
About the IRF3-mediated induction of type I IFN Pathway
The IRF3-mediated induction of type I IFN pathway is catalogued in Reactome (ID: R-HSA-3270619) and involves 2 genes. In the BiohacksAI corpus, 4 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PRKDC, TBK1.