What compounds affect the Metabolism of polyamines pathway?

23 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolism of polyamines pathway (Reactome ID: R-HSA-351202). These compounds target 38 genes within this pathway.

What genes are in the Metabolism of polyamines pathway?

The Metabolism of polyamines pathway involves 38 genes. Key genes include: ADRM1, NQO1, OAZ1, ODC1, PAOX, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5.

Metabolism of polyamines

REACTOME PATHWAY

Reactome: R-HSA-35120238 genes23 compounds

The Metabolism of polyamines pathway (Reactome ID: R-HSA-351202) involves 38 genes and is affected by 23 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 NQO1 OAZ1 ODC1 PAOX PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14+8 more

Compounds Affecting Metabolism of polyamines

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Spermine	—	300
4	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
5	Chlorhexidine	—	299
6	Disulfiram	—	297
7	4-Hydroxybenzoate-3-Monooxygenase	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	chrysin	—	300
10	egcg	—	300
11	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
12	Quercetin	—	300
13	Genistein	—	300
14	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
15	alyssin [Supplementary Concept]	—	300
16	Vitamin K 3	—	300
17	Hydrogen Peroxide	—	299
18	Diminazene	—	300
19	pentamidine	—	299
20	Eflornithine	—	298
21	Vincristine	—	299
22	Pioglitazone	—	297
23	Harmaline	—	300

About the Metabolism of polyamines Pathway

The Metabolism of polyamines pathway is catalogued in Reactome (ID: R-HSA-351202) and involves 38 genes. In the BiohacksAI corpus, 23 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, NQO1, OAZ1, ODC1, PAOX.