Nephrin family interactions
REACTOME PATHWAYThe Nephrin family interactions pathway (Reactome ID: R-HSA-373753) involves 5 genes and is affected by 17 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Nephrin family interactions
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | pictilisib | — | 25 |
| 2 | ly294002 | — | 11 |
| 3 | Sirolimus | — | 300 |
| 4 | Crizotinib | — | 298 |
| 5 | Wortmannin | — | 300 |
| 6 | alpelisib | — | 227 |
| 7 | Rosmarinic Acid | — | 300 |
| 8 | Genistein | — | 300 |
| 9 | Dasatinib | — | 299 |
| 10 | egcg | — | 300 |
| 11 | Acetic Acid Product of | — | 300 |
| 12 | kenpaullone | — | 8 |
| 13 | Sorafenib | — | 300 |
| 14 | tyrphostin ag 1478 | — | 4 |
| 15 | torin 1 | — | 10 |
| 16 | Quercetin | — | 300 |
| 17 | Resveratrol | — | 298 |
About the Nephrin family interactions Pathway
The Nephrin family interactions pathway is catalogued in Reactome (ID: R-HSA-373753) and involves 5 genes. In the BiohacksAI corpus, 17 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASK, FYN, PIK3CB, PIK3R1, PIK3R2.