Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
REACTOME PATHWAYThe Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway (Reactome ID: R-HSA-381771) involves 5 genes and is affected by 26 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Linoleic Acid | — | 300 |
| 2 | alpha-Linolenic Acid | — | 300 |
| 3 | Oleic Acid | — | 112 |
| 4 | Myristic Acid | — | 300 |
| 5 | Dihydroergotamine | — | 9 |
| 6 | Sitagliptin Phosphate | — | 990 |
| 7 | Kaempferols | — | 300 |
| 8 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 9 | caffeic acid | — | 300 |
| 10 | Genistein | — | 300 |
| 11 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 12 | Kaempferols | — | 300 |
| 13 | Quercetin | — | 300 |
| 14 | Resveratrol | — | 298 |
| 15 | Hesperidin | — | 300 |
| 16 | Vidarabine | — | 299 |
| 17 | Dehydroepiandrosterone Sulfate | — | 300 |
| 18 | Palmitic Acid | — | 300 |
| 19 | gamma-Linolenic Acid | — | 300 |
| 20 | Tolterodine Tartrate | — | 73 |
| 21 | Ouabain | — | 300 |
| 22 | palmidrol [Supplementary Concept] | — | 300 |
| 23 | Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide. | — | 300 |
| 24 | Masoprocol | — | 300 |
| 25 | Perphenazine | — | 297 |
| 26 | pnu74654 | — | 6 |
About the Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Pathway
The Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway is catalogued in Reactome (ID: R-HSA-381771) and involves 5 genes. In the BiohacksAI corpus, 26 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DPP4, FFAR1, FFAR4, GPR119, TCF7L2.