What compounds affect the Co-inhibition by CTLA4 pathway?

28 compounds in the BiohacksAI corpus have documented interactions with genes in the Co-inhibition by CTLA4 pathway (Reactome ID: R-HSA-389513). These compounds target 8 genes within this pathway.

What genes are in the Co-inhibition by CTLA4 pathway?

The Co-inhibition by CTLA4 pathway involves 8 genes. Key genes include: AKT3, FYN, LCK, LYN, PPP2CA, PPP2R5A, SRC, YES1.

Co-inhibition by CTLA4

REACTOME PATHWAY

Reactome: R-HSA-3895138 genes28 compounds

The Co-inhibition by CTLA4 pathway (Reactome ID: R-HSA-389513) involves 8 genes and is affected by 28 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 FYN LCK LYN PPP2CA PPP2R5A SRC YES1

Compounds Affecting Co-inhibition by CTLA4

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Crizotinib	—	298
3	Sorafenib	—	300
4	tyrphostin ag 1478	—	4
5	kenpaullone	—	8
6	Quercetin	—	300
7	Axitinib	—	298
8	Afatinib	—	297
9	alsterpaullone	—	12
10	Acetic Acid Product of	—	300
11	sp600125	—	117
12	Okadaic Acid	—	300
13	Kaempferols	—	300
14	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
15	Cladribine	—	297
16	pictilisib	—	25
17	Pioglitazone	—	297
18	Vemurafenib	—	298
19	Resveratrol	—	298
20	Adenosine Monophosphate Adenine nucleotide containing	—	300
21	monorden	—	8
22	Niclosamide	—	299
23	piceatannol	—	300
24	Swainsonine	—	300
25	Rosmarinic Acid	—	300
26	Genistein	—	300
27	egcg	—	300
28	hydroxyfasudil [Supplementary Concept]	—	11

About the Co-inhibition by CTLA4 Pathway

The Co-inhibition by CTLA4 pathway is catalogued in Reactome (ID: R-HSA-389513) and involves 8 genes. In the BiohacksAI corpus, 28 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, FYN, LCK, LYN, PPP2CA.