What genes are in the SUMOylation of transcription cofactors pathway?

The SUMOylation of transcription cofactors pathway involves 8 genes. Key genes include: CREBBP, CTBP1, EP300, HIPK2, NCOA1, NCOR2, NPM1, SUMO1.

SUMOylation of transcription cofactors

Q: What compounds affect the SUMOylation of transcription cofactors pathway?

39 compounds in the BiohacksAI corpus have documented interactions with genes in the SUMOylation of transcription cofactors pathway (Reactome ID: R-HSA-3899300). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-38993008 genes39 compounds

The SUMOylation of transcription cofactors pathway (Reactome ID: R-HSA-3899300) involves 8 genes and is affected by 39 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREBBP CTBP1 EP300 HIPK2 NCOA1 NCOR2 NPM1 SUMO1

Compounds Affecting SUMOylation of transcription cofactors

#	Compound	Targets Hit	Studies
1	Methylene Blue	—	200
2	Anisomycin	—	247
3	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
4	Digoxin	—	299
5	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
6	Tubercidin	—	300
7	Methotrexate	—	289
8	Azacitidine	—	298
9	Azacitidine	—	300
10	cycloheximide	—	300
11	Famotidine	—	296
12	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
13	Trifluridine	—	295
14	urolithin b	—	49
15	NAD	—	300
16	NAD	—	300
17	NAD	—	300
18	Carmine Coloring matter from	—	300
19	Diiodotyrosine	—	300
20	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
21	Vorinostat	—	299
22	scriptaid	—	53
23	Biotin	—	297
24	Cefdinir	—	298
25	Cefixime	—	300
26	Hexachlorophene	—	300
27	Oxytetracycline	—	300
28	Papaverine	—	299
29	Colchicine	—	300
30	Etazolate	—	66
31	Nocodazole Nocodazole is	—	215
32	Sorafenib	—	300
33	sp600125	—	117
34	ly294002	—	11
35	pictilisib	—	25
36	plumbagin [Supplementary Concept]	—	300
37	egcg	—	300
38	11-hydroxypalmatine [Supplementary Concept]	—	238
39	Crizotinib	—	298

About the SUMOylation of transcription cofactors Pathway

The SUMOylation of transcription cofactors pathway is catalogued in Reactome (ID: R-HSA-3899300) and involves 8 genes. In the BiohacksAI corpus, 39 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREBBP, CTBP1, EP300, HIPK2, NCOA1.