Signal regulatory protein family interactions
REACTOME PATHWAYThe Signal regulatory protein family interactions pathway (Reactome ID: R-HSA-391160) involves 6 genes and is affected by 22 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Signal regulatory protein family interactions
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Crizotinib | — | 298 |
| 3 | Aurintricarboxylic Acid | — | 184 |
| 4 | Histidine | — | 158 |
| 5 | Fusaric Acid | — | 300 |
| 6 | Idarubicin | — | 299 |
| 7 | Mimosine 3-Hydroxy-4-oxo-1(4H)-pyridinealanine. | — | 300 |
| 8 | Dasatinib | — | 299 |
| 9 | Resveratrol | — | 298 |
| 10 | tyrphostin ag 1478 | — | 4 |
| 11 | Quercetin | — | 300 |
| 12 | Adenosine Monophosphate Adenine nucleotide containing | — | 300 |
| 13 | Afatinib | — | 297 |
| 14 | alsterpaullone | — | 12 |
| 15 | kenpaullone | — | 8 |
| 16 | monorden | — | 8 |
| 17 | Niclosamide | — | 299 |
| 18 | cycloheximide | — | 300 |
| 19 | Pioglitazone | — | 297 |
| 20 | Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione. | — | 300 |
| 21 | celastrol | — | 300 |
| 22 | Dactinomycin | — | 297 |
About the Signal regulatory protein family interactions Pathway
The Signal regulatory protein family interactions pathway is catalogued in Reactome (ID: R-HSA-391160) and involves 6 genes. In the BiohacksAI corpus, 22 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CD47, GRB2, PTK2B, PTPN6, SIRPA.