What compounds affect the CRMPs in Sema3A signaling pathway?

27 compounds in the BiohacksAI corpus have documented interactions with genes in the CRMPs in Sema3A signaling pathway (Reactome ID: R-HSA-399956). These compounds target 6 genes within this pathway.

What genes are in the CRMPs in Sema3A signaling pathway?

The CRMPs in Sema3A signaling pathway involves 6 genes. Key genes include: CDK5, CDK5R1, DPYSL2, FES, FYN, GSK3B.

CRMPs in Sema3A signaling

REACTOME PATHWAY

Reactome: R-HSA-3999566 genes27 compounds

The CRMPs in Sema3A signaling pathway (Reactome ID: R-HSA-399956) involves 6 genes and is affected by 27 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK5 CDK5R1 DPYSL2 FES FYN GSK3B

Compounds Affecting CRMPs in Sema3A signaling

#	Compound	Targets Hit	Studies
1	kenpaullone	—	8
2	egcg	—	300
3	alsterpaullone	—	12
4	indirubin	—	300
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
7	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
8	chrysin	—	300
9	fisetin	—	78
10	Sorafenib	—	300
11	sp600125	—	117
12	Dasatinib	—	299
13	Crizotinib	—	298
14	Kaempferols	—	300
15	Quercetin	—	300
16	Lithium Chloride	—	300
17	ly294002	—	11
18	Rutin	—	300
19	Ursolic Acid	—	300
20	Oleanolic Acid	—	300
21	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
22	hydroxyfasudil [Supplementary Concept]	—	11
23	Rosmarinic Acid	—	300
24	Genistein	—	300
25	Acetic Acid Product of	—	300
26	tyrphostin ag 1478	—	4
27	Ergosterol	—	300

About the CRMPs in Sema3A signaling Pathway

The CRMPs in Sema3A signaling pathway is catalogued in Reactome (ID: R-HSA-399956) and involves 6 genes. In the BiohacksAI corpus, 27 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK5, CDK5R1, DPYSL2, FES, FYN.