Role of ABL in ROBO-SLIT signaling
REACTOME PATHWAYThe Role of ABL in ROBO-SLIT signaling pathway (Reactome ID: R-HSA-428890) involves 2 genes and is affected by 21 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Role of ABL in ROBO-SLIT signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Axitinib | — | 298 |
| 3 | Dasatinib | — | 299 |
| 4 | Crizotinib | — | 298 |
| 5 | tyrphostin ag 1478 | — | 4 |
| 6 | Afatinib | — | 297 |
| 7 | Avapritinib | — | 246 |
| 8 | Biotin | — | 297 |
| 9 | 19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept] | — | 300 |
| 10 | Imatinib Mesylate | — | 300 |
| 11 | triolimus [Supplementary Concept] | — | 33 |
| 12 | Genistein | — | 300 |
| 13 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 14 | pterostilbene | — | 299 |
| 15 | Quercetin | — | 300 |
| 16 | Adenosine Triphosphate | — | 300 |
| 17 | alpelisib | — | 227 |
| 18 | alsterpaullone | — | 12 |
| 19 | kenpaullone | — | 8 |
| 20 | Nocodazole Nocodazole is | — | 215 |
| 21 | Oxytetracycline | — | 300 |
About the Role of ABL in ROBO-SLIT signaling Pathway
The Role of ABL in ROBO-SLIT signaling pathway is catalogued in Reactome (ID: R-HSA-428890) and involves 2 genes. In the BiohacksAI corpus, 21 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ABL2.