B-WICH complex positively regulates rRNA expression

Q: What compounds affect the B-WICH complex positively regulates rRNA expression pathway?

42 compounds in the BiohacksAI corpus have documented interactions with genes in the B-WICH complex positively regulates rRNA expression pathway (Reactome ID: R-HSA-5250924). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-52509244 genes42 compounds

The B-WICH complex positively regulates rRNA expression pathway (Reactome ID: R-HSA-5250924) involves 4 genes and is affected by 42 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

EP300 GSK3B KAT2A KAT2B

Compounds Affecting B-WICH complex positively regulates rRNA expression

#	Compound	Targets Hit	Studies
1	egcg	—	300
2	plumbagin [Supplementary Concept]	—	300
3	Aurintricarboxylic Acid	—	184
4	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
5	DEAD-box RNA Helicases	—	169
6	Thioctic Acid	—	298
7	Arachidonic Acid	—	245
8	Oleic Acid	—	112
9	alpha-Linolenic Acid	—	300
10	candesartan cilexetil [Supplementary Concept]	—	300
11	Cisplatin	—	300
12	diallyl trisulfide	—	246
13	Estramustine	—	300
14	gamma-Linolenic Acid	—	300
15	Hexachlorophene	—	300
16	Iodoacetamide	—	300
17	Lithocholic Acid	—	300
18	Oxytetracycline	—	300
19	rafoxanide	—	172
20	Ritonavir	—	298
21	Thioctic Acid	—	300
22	Trazodone	—	297
23	alsterpaullone	—	12
24	kenpaullone	—	8
25	indirubin	—	300
26	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
27	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
28	Kaempferols	—	300
29	Quercetin	—	300
30	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
31	Lithium Chloride	—	300
32	chrysin	—	300
33	fisetin	—	78
34	ly294002	—	11
35	Sorafenib	—	300
36	Rutin	—	300
37	Ursolic Acid	—	300
38	Oleanolic Acid	—	300
39	sp600125	—	117
40	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
41	11-hydroxypalmatine [Supplementary Concept]	—	238
42	np1	—	81

About the B-WICH complex positively regulates rRNA expression Pathway

The B-WICH complex positively regulates rRNA expression pathway is catalogued in Reactome (ID: R-HSA-5250924) and involves 4 genes. In the BiohacksAI corpus, 42 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EP300, GSK3B, KAT2A, KAT2B.