What compounds affect the Hedgehog ligand biogenesis pathway?

24 compounds in the BiohacksAI corpus have documented interactions with genes in the Hedgehog ligand biogenesis pathway (Reactome ID: R-HSA-5358346). These compounds target 35 genes within this pathway.

What genes are in the Hedgehog ligand biogenesis pathway?

The Hedgehog ligand biogenesis pathway involves 35 genes. Key genes include: ADAM17, ADRM1, P4HB, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7.

Hedgehog ligand biogenesis

REACTOME PATHWAY

Reactome: R-HSA-535834635 genes24 compounds

The Hedgehog ligand biogenesis pathway (Reactome ID: R-HSA-5358346) involves 35 genes and is affected by 24 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM17 ADRM1 P4HB PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3+5 more

Compounds Affecting Hedgehog ligand biogenesis

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	egcg	—	300
4	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
5	Disulfiram	—	297
6	4-Hydroxybenzoate-3-Monooxygenase	—	300
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	chrysin	—	300
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	Quercetin	—	300
11	Genistein	—	300
12	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
13	Hexachlorophene	—	300
14	Oxytetracycline	—	300
15	Clotrimazole	—	296
16	Demeclocycline	—	5
17	Edaravone	—	298
18	Bisphenol A-Glycidyl Methacrylate	—	197
19	Kaempferols	—	300
20	Prednisolone	—	1,000
21	Pioglitazone	—	297
22	Harmaline	—	300
23	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
24	Equilin	—	216

About the Hedgehog ligand biogenesis Pathway

The Hedgehog ligand biogenesis pathway is catalogued in Reactome (ID: R-HSA-5358346) and involves 35 genes. In the BiohacksAI corpus, 24 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM17, ADRM1, P4HB, PSMA1, PSMA2.