Hh mutants are degraded by ERAD
REACTOME PATHWAYThe Hh mutants are degraded by ERAD pathway (Reactome ID: R-HSA-5362768) involves 33 genes and is affected by 19 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Hh mutants are degraded by ERAD
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Bortezomib | — | 300 |
| 2 | Reserpine | — | 297 |
| 3 | egcg | — | 300 |
| 4 | Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as | — | 300 |
| 5 | Disulfiram | — | 297 |
| 6 | 4-Hydroxybenzoate-3-Monooxygenase | — | 300 |
| 7 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 8 | chrysin | — | 300 |
| 9 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 10 | Quercetin | — | 300 |
| 11 | Genistein | — | 300 |
| 12 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 13 | Hexachlorophene | — | 300 |
| 14 | Oxytetracycline | — | 300 |
| 15 | Clotrimazole | — | 296 |
| 16 | Demeclocycline | — | 5 |
| 17 | Edaravone | — | 298 |
| 18 | Pioglitazone | — | 297 |
| 19 | Harmaline | — | 300 |
About the Hh mutants are degraded by ERAD Pathway
The Hh mutants are degraded by ERAD pathway is catalogued in Reactome (ID: R-HSA-5362768) and involves 33 genes. In the BiohacksAI corpus, 19 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, PSMA1, PSMA2, PSMA3, PSMA4.