IRAK4 deficiency (TLR2/4)
REACTOME PATHWAYThe IRAK4 deficiency (TLR2/4) pathway (Reactome ID: R-HSA-5603041) involves 4 genes and is affected by 8 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting IRAK4 deficiency (TLR2/4)
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Dasatinib | — | 299 |
| 2 | Crizotinib | — | 298 |
| 3 | tyrphostin ag 1478 | — | 4 |
| 4 | Methotrexate | — | 289 |
| 5 | Salicylic Acid | — | 298 |
| 6 | sp600125 | — | 117 |
| 7 | Myristic Acid | — | 300 |
| 8 | Palmitic Acid | — | 300 |
About the IRAK4 deficiency (TLR2/4) Pathway
The IRAK4 deficiency (TLR2/4) pathway is catalogued in Reactome (ID: R-HSA-5603041) and involves 4 genes. In the BiohacksAI corpus, 8 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BTK, HMGB1, IRAK4, TLR2.