RHO GTPases activate PAKs
REACTOME PATHWAYThe RHO GTPases activate PAKs pathway (Reactome ID: R-HSA-5627123) involves 3 genes and is affected by 9 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting RHO GTPases activate PAKs
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Wortmannin | — | 300 |
| 2 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 3 | hydroxyfasudil [Supplementary Concept] | — | 11 |
| 4 | sp600125 | — | 117 |
| 5 | Sorafenib | — | 300 |
| 6 | Crizotinib | — | 298 |
| 7 | Dasatinib | — | 299 |
| 8 | kenpaullone | — | 8 |
| 9 | casin | — | 10 |
About the RHO GTPases activate PAKs Pathway
The RHO GTPases activate PAKs pathway is catalogued in Reactome (ID: R-HSA-5627123) and involves 3 genes. In the BiohacksAI corpus, 9 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDC42, LIMK1, MYLK.