Regulation of TLR by endogenous ligand
REACTOME PATHWAYThe Regulation of TLR by endogenous ligand pathway (Reactome ID: R-HSA-5686938) involves 3 genes and is affected by 5 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Regulation of TLR by endogenous ligand
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Methotrexate | — | 289 |
| 2 | Salicylic Acid | — | 298 |
| 3 | Myristic Acid | — | 300 |
| 4 | Palmitic Acid | — | 300 |
| 5 | Disulfiram | — | 297 |
About the Regulation of TLR by endogenous ligand Pathway
The Regulation of TLR by endogenous ligand pathway is catalogued in Reactome (ID: R-HSA-5686938) and involves 3 genes. In the BiohacksAI corpus, 5 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GSDMD, HMGB1, TLR2.