COPI-mediated anterograde transport
REACTOME PATHWAYThe COPI-mediated anterograde transport pathway (Reactome ID: R-HSA-6807878) involves 19 genes and is affected by 17 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting COPI-mediated anterograde transport
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Colchicine | — | 300 |
| 2 | Nocodazole Nocodazole is | — | 215 |
| 3 | Vincristine | — | 299 |
| 4 | Noscapine | — | 300 |
| 5 | Podophyllotoxin | — | 14 |
| 6 | Demecolcine | — | 246 |
| 7 | Maytansine | — | 300 |
| 8 | vinblastine sulfate | — | 81 |
| 9 | Vorinostat | — | 299 |
| 10 | Digitoxin | — | 300 |
| 11 | Digoxin | — | 299 |
| 12 | Flutamide | — | 298 |
| 13 | m084 | — | 2 |
| 14 | Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against | — | 299 |
| 15 | Pemetrexed | — | 299 |
| 16 | Methotrexate | — | 289 |
| 17 | Folic Acid | — | 296 |
About the COPI-mediated anterograde transport Pathway
The COPI-mediated anterograde transport pathway is catalogued in Reactome (ID: R-HSA-6807878) and involves 19 genes. In the BiohacksAI corpus, 17 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FOLR1, INS, TUBA1A, TUBA1B, TUBA1C.