What compounds affect the Orc1 removal from chromatin pathway?

22 compounds in the BiohacksAI corpus have documented interactions with genes in the Orc1 removal from chromatin pathway (Reactome ID: R-HSA-68949). These compounds target 36 genes within this pathway.

What genes are in the Orc1 removal from chromatin pathway?

The Orc1 removal from chromatin pathway involves 36 genes. Key genes include: ADRM1, CCNA1, CDK2, CUL1, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6.

Orc1 removal from chromatin

REACTOME PATHWAY

Reactome: R-HSA-6894936 genes22 compounds

The Orc1 removal from chromatin pathway (Reactome ID: R-HSA-68949) involves 36 genes and is affected by 22 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CCNA1 CDK2 CUL1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2+6 more

Compounds Affecting Orc1 removal from chromatin

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
4	alsterpaullone	—	12
5	kenpaullone	—	8
6	sp600125	—	117
7	ninhydrin	—	300
8	Disulfiram	—	297
9	4-Hydroxybenzoate-3-Monooxygenase	—	300
10	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
11	chrysin	—	300
12	egcg	—	300
13	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
14	Quercetin	—	300
15	Genistein	—	300
16	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
17	Aurintricarboxylic Acid	—	184
18	Methylergonovine	—	14
19	candesartan cilexetil [Supplementary Concept]	—	300
20	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
21	Pioglitazone	—	297
22	Harmaline	—	300

About the Orc1 removal from chromatin Pathway

The Orc1 removal from chromatin pathway is catalogued in Reactome (ID: R-HSA-68949) and involves 36 genes. In the BiohacksAI corpus, 22 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CCNA1, CDK2, CUL1, PSMA1.