CDK-mediated phosphorylation and removal of Cdc6
REACTOME PATHWAYThe CDK-mediated phosphorylation and removal of Cdc6 pathway (Reactome ID: R-HSA-69017) involves 35 genes and is affected by 20 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting CDK-mediated phosphorylation and removal of Cdc6
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Bortezomib | — | 300 |
| 2 | Reserpine | — | 297 |
| 3 | alsterpaullone | — | 12 |
| 4 | kenpaullone | — | 8 |
| 5 | Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as | — | 300 |
| 6 | sp600125 | — | 117 |
| 7 | Disulfiram | — | 297 |
| 8 | 4-Hydroxybenzoate-3-Monooxygenase | — | 300 |
| 9 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 10 | chrysin | — | 300 |
| 11 | egcg | — | 300 |
| 12 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 13 | Quercetin | — | 300 |
| 14 | Genistein | — | 300 |
| 15 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 16 | Aurintricarboxylic Acid | — | 184 |
| 17 | Methylergonovine | — | 14 |
| 18 | Adenosine Triphosphate | — | 300 |
| 19 | Pioglitazone | — | 297 |
| 20 | Harmaline | — | 300 |
About the CDK-mediated phosphorylation and removal of Cdc6 Pathway
The CDK-mediated phosphorylation and removal of Cdc6 pathway is catalogued in Reactome (ID: R-HSA-69017) and involves 35 genes. In the BiohacksAI corpus, 20 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CCNA1, CCNE2, CDK2, PSMA1.