What compounds affect the Purine catabolism pathway?

17 compounds in the BiohacksAI corpus have documented interactions with genes in the Purine catabolism pathway (Reactome ID: R-HSA-74259). These compounds target 3 genes within this pathway.

What genes are in the Purine catabolism pathway?

The Purine catabolism pathway involves 3 genes. Key genes include: GDA, PNP, XDH.

Purine catabolism

REACTOME PATHWAY

Reactome: R-HSA-742593 genes17 compounds

The Purine catabolism pathway (Reactome ID: R-HSA-74259) involves 3 genes and is affected by 17 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GDA PNP XDH

Compounds Affecting Purine catabolism

#	Compound	Targets Hit	Studies
1	Febuxostat	—	297
2	Quercetin	—	300
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
5	chrysin	—	300
6	Oxypurinol	—	300
7	fisetin	—	78
8	Genistein	—	300
9	Kaempferols	—	300
10	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
11	Hesperidin	—	300
12	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
13	Caffeine	—	299
14	Aminoimidazole Carboxamide	—	121
15	Uric Acid	—	298
16	Xanthine	—	298
17	guanine	—	299

About the Purine catabolism Pathway

The Purine catabolism pathway is catalogued in Reactome (ID: R-HSA-74259) and involves 3 genes. In the BiohacksAI corpus, 17 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GDA, PNP, XDH.