Apoptotic execution phase
REACTOME PATHWAYThe Apoptotic execution phase pathway (Reactome ID: R-HSA-75153) involves 6 genes and is affected by 9 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Apoptotic execution phase
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Crizotinib | — | 298 |
| 2 | Methotrexate | — | 289 |
| 3 | Salicylic Acid | — | 298 |
| 4 | Chlorhexidine | — | 299 |
| 5 | Reserpine | — | 297 |
| 6 | Dasatinib | — | 299 |
| 7 | Lovastatin | — | 300 |
| 8 | Gliotoxin | — | 300 |
| 9 | Histamine | — | 300 |
About the Apoptotic execution phase Pathway
The Apoptotic execution phase pathway is catalogued in Reactome (ID: R-HSA-75153) and involves 6 genes. In the BiohacksAI corpus, 9 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BMX, FNTA, HMGB1, KPNB1, LMNA.