What genes are in the Ubiquitin-dependent degradation of Cyclin D pathway?

The Ubiquitin-dependent degradation of Cyclin D pathway involves 34 genes. Key genes include: ADRM1, CDK4, GSK3B, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7.

Ubiquitin-dependent degradation of Cyclin D

Q: What compounds affect the Ubiquitin-dependent degradation of Cyclin D pathway?

28 compounds in the BiohacksAI corpus have documented interactions with genes in the Ubiquitin-dependent degradation of Cyclin D pathway (Reactome ID: R-HSA-75815). These compounds target 34 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-7581534 genes28 compounds

The Ubiquitin-dependent degradation of Cyclin D pathway (Reactome ID: R-HSA-75815) involves 34 genes and is affected by 28 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CDK4 GSK3B PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3+4 more

Compounds Affecting Ubiquitin-dependent degradation of Cyclin D

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	indirubin	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
6	Quercetin	—	300
7	chrysin	—	300
8	egcg	—	300
9	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
10	alsterpaullone	—	12
11	kenpaullone	—	8
12	Kaempferols	—	300
13	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
14	Lithium Chloride	—	300
15	fisetin	—	78
16	ly294002	—	11
17	Sorafenib	—	300
18	Rutin	—	300
19	Ursolic Acid	—	300
20	Oleanolic Acid	—	300
21	sp600125	—	117
22	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
23	Disulfiram	—	297
24	4-Hydroxybenzoate-3-Monooxygenase	—	300
25	Genistein	—	300
26	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
27	Pioglitazone	—	297
28	Harmaline	—	300

About the Ubiquitin-dependent degradation of Cyclin D Pathway

The Ubiquitin-dependent degradation of Cyclin D pathway is catalogued in Reactome (ID: R-HSA-75815) and involves 34 genes. In the BiohacksAI corpus, 28 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CDK4, GSK3B, PSMA1, PSMA2.