What compounds affect the Insulin receptor recycling pathway?

31 compounds in the BiohacksAI corpus have documented interactions with genes in the Insulin receptor recycling pathway (Reactome ID: R-HSA-77387). These compounds target 6 genes within this pathway.

What genes are in the Insulin receptor recycling pathway?

The Insulin receptor recycling pathway involves 6 genes. Key genes include: ATP6V1B2, IDE, INS, INSR, PTPN1, PTPRF.

Insulin receptor recycling

REACTOME PATHWAY

Reactome: R-HSA-773876 genes31 compounds

The Insulin receptor recycling pathway (Reactome ID: R-HSA-77387) involves 6 genes and is affected by 31 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATP6V1B2 IDE INS INSR PTPN1 PTPRF

Compounds Affecting Insulin receptor recycling

#	Compound	Targets Hit	Studies
1	Ursolic Acid	—	300
2	Oleanolic Acid	—	300
3	celastrol	—	300
4	Okadaic Acid	—	300
5	caffeic acid	—	300
6	Chlorogenic Acid	—	300
7	Methylene Blue	—	200
8	Oleic Acid	—	112
9	Mepentol [Supplementary Concept]	—	184
10	Evans Blue	—	300
11	Lithocholic Acid	—	300
12	Palmitic Acid	—	300
13	prunetin	—	35
14	Suramin	—	300
15	vanadates	—	284
16	Crizotinib	—	298
17	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
18	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
19	Sorafenib	—	300
20	sp600125	—	117
21	Biotin	—	297
22	ag490	—	14
23	Cefmetazole	—	300
24	Ethylmaleimide	—	300
25	gedunin	—	54
26	Digitoxin	—	300
27	Digoxin	—	299
28	Flutamide	—	298
29	m084	—	2
30	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
31	Enoxacin	—	299

About the Insulin receptor recycling Pathway

The Insulin receptor recycling pathway is catalogued in Reactome (ID: R-HSA-77387) and involves 6 genes. In the BiohacksAI corpus, 31 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATP6V1B2, IDE, INS, INSR, PTPN1.