MET activates PI3K/AKT signaling
REACTOME PATHWAYThe MET activates PI3K/AKT signaling pathway (Reactome ID: R-HSA-8851907) involves 3 genes and is affected by 15 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting MET activates PI3K/AKT signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Quercetin | — | 300 |
| 2 | Crizotinib | — | 298 |
| 3 | Afatinib | — | 297 |
| 4 | egcg | — | 300 |
| 5 | Axitinib | — | 298 |
| 6 | Sorafenib | — | 300 |
| 7 | Adenosine Triphosphate | — | 300 |
| 8 | sp600125 | — | 117 |
| 9 | pictilisib | — | 25 |
| 10 | Wortmannin | — | 300 |
| 11 | ly294002 | — | 11 |
| 12 | alpelisib | — | 227 |
| 13 | Sirolimus | — | 300 |
| 14 | torin 1 | — | 10 |
| 15 | Dactinomycin | — | 297 |
About the MET activates PI3K/AKT signaling Pathway
The MET activates PI3K/AKT signaling pathway is catalogued in Reactome (ID: R-HSA-8851907) and involves 3 genes. In the BiohacksAI corpus, 15 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GRB2, MET, PIK3R1.