Regulation of RUNX1 Expression and Activity
REACTOME PATHWAYThe Regulation of RUNX1 Expression and Activity pathway (Reactome ID: R-HSA-8934593) involves 5 genes and is affected by 25 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Regulation of RUNX1 Expression and Activity
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Aurintricarboxylic Acid | — | 184 |
| 3 | Dihydroxyphenylalanine | — | 300 |
| 4 | Disulfiram | — | 297 |
| 5 | Ethidium | — | 300 |
| 6 | juglone hydroxylase [Supplementary Concept] catalyzes | — | 279 |
| 7 | Daunorubicin | — | 298 |
| 8 | Fusaric Acid | — | 300 |
| 9 | Harmaline | — | 300 |
| 10 | Dasatinib | — | 299 |
| 11 | Resveratrol | — | 298 |
| 12 | tyrphostin ag 1478 | — | 4 |
| 13 | Quercetin | — | 300 |
| 14 | Adenosine Monophosphate Adenine nucleotide containing | — | 300 |
| 15 | Afatinib | — | 297 |
| 16 | alsterpaullone | — | 12 |
| 17 | Crizotinib | — | 298 |
| 18 | kenpaullone | — | 8 |
| 19 | monorden | — | 8 |
| 20 | Niclosamide | — | 299 |
| 21 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 22 | chrysin | — | 300 |
| 23 | fisetin | — | 78 |
| 24 | indirubin | — | 300 |
| 25 | Sulfisomidine | — | 73 |
About the Regulation of RUNX1 Expression and Activity Pathway
The Regulation of RUNX1 Expression and Activity pathway is catalogued in Reactome (ID: R-HSA-8934593) and involves 5 genes. In the BiohacksAI corpus, 25 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, CBFB, CDK6, RUNX1, SRC.