RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Q: What compounds affect the RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function pathway?

41 compounds in the BiohacksAI corpus have documented interactions with genes in the RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function pathway (Reactome ID: R-HSA-8936459). These compounds target 13 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-893645913 genes41 compounds

The RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function pathway (Reactome ID: R-HSA-8936459) involves 13 genes and is affected by 41 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ASH2L CBFB DPY30 EP300 HDAC1 ITGA2B KAT2B KMT2A PRMT1 PRMT6 RBBP5 RUNX1 WDR5

Compounds Affecting RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

#	Compound	Targets Hit	Studies
1	s adenosylhomocysteine	—	300
2	Disulfiram	—	297
3	Ethidium	—	300
4	Daunorubicin	—	298
5	Aurintricarboxylic Acid	—	184
6	Suramin	—	300
7	Dihydroxyphenylalanine	—	300
8	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
9	Fusaric Acid	—	300
10	Harmaline	—	300
11	plumbagin [Supplementary Concept]	—	300
12	egcg	—	300
13	pentamidine	—	299
14	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
15	Sulfinpyrazone	—	300
16	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
17	Calcimycin	—	216
18	cefaclor	—	299
19	Cefixime	—	300
20	Cefotetan	—	299
21	Demeclocycline	—	5
22	hydroxyindoleacetic acid	—	300
23	Metergoline	—	144
24	Nisoldipine	—	297
25	Nitrofurantoin	—	297
26	Vorinostat	—	299
27	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
28	scriptaid	—	53
29	Valproic Acid	—	296
30	pictilisib	—	25
31	Butyric Acid	—	300
32	Ursolic Acid	—	300
33	Celecoxib	—	295
34	Bortezomib	—	300
35	Camptothecin	—	300
36	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
37	Nitroblue Tetrazolium Colorless to yellow dye that is reducible to blue or black formazan crystals by certain cells; formerly used to distinguish between nonbacterial and bacterial diseases,	—	300
38	scutellarein	—	113
39	11-hydroxypalmatine [Supplementary Concept]	—	238
40	np1	—	81
41	Tirofiban Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in	—	299

About the RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Pathway

The RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function pathway is catalogued in Reactome (ID: R-HSA-8936459) and involves 13 genes. In the BiohacksAI corpus, 41 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ASH2L, CBFB, DPY30, EP300, HDAC1.