What genes are in the Regulation of expression of SLITs and ROBOs pathway?

The Regulation of expression of SLITs and ROBOs pathway involves 36 genes. Key genes include: ADRM1, EIF4G1, PABPC1, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7.

Regulation of expression of SLITs and ROBOs

Q: What compounds affect the Regulation of expression of SLITs and ROBOs pathway?

31 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of expression of SLITs and ROBOs pathway (Reactome ID: R-HSA-9010553). These compounds target 36 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-901055336 genes31 compounds

The Regulation of expression of SLITs and ROBOs pathway (Reactome ID: R-HSA-9010553) involves 36 genes and is affected by 31 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 EIF4G1 PABPC1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3+6 more

Compounds Affecting Regulation of expression of SLITs and ROBOs

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	egcg	—	300
4	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
5	Hexachlorophene	—	300
6	Oxytetracycline	—	300
7	Disulfiram	—	297
8	4-Hydroxybenzoate-3-Monooxygenase	—	300
9	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
10	chrysin	—	300
11	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
12	Quercetin	—	300
13	Genistein	—	300
14	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
15	Oxcarbazepine	—	296
16	Rosmarinic Acid	—	300
17	Rutin	—	300
18	Anthralin	—	299
19	Cefixime	—	300
20	Ethidium	—	300
21	Phenoxybenzamine	—	21
22	sp600125	—	117
23	Temozolomide	—	299
24	DEAD-box RNA Helicases	—	169
25	Thioctic Acid	—	298
26	Thioctic Acid	—	300
27	Azauridine	—	300
28	Levetiracetam	—	296
29	Pioglitazone	—	297
30	Harmaline	—	300
31	ninhydrin	—	300

About the Regulation of expression of SLITs and ROBOs Pathway

The Regulation of expression of SLITs and ROBOs pathway is catalogued in Reactome (ID: R-HSA-9010553) and involves 36 genes. In the BiohacksAI corpus, 31 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, EIF4G1, PABPC1, PSMA1, PSMA2.