Interleukin-18 signaling
REACTOME PATHWAYThe Interleukin-18 signaling pathway (Reactome ID: R-HSA-9012546) involves 1 genes and is affected by 14 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Interleukin-18 signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Masoprocol | — | 300 |
| 2 | Quercetin | — | 300 |
| 3 | pterostilbene | — | 299 |
| 4 | piceatannol | — | 300 |
| 5 | butein | — | 158 |
| 6 | Celecoxib | — | 295 |
| 7 | caffeic acid | — | 300 |
| 8 | Kaempferols | — | 300 |
| 9 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 10 | Resveratrol | — | 298 |
| 11 | Anthralin | — | 299 |
| 12 | Bufexamac | — | 137 |
| 13 | Indomethacin | — | 297 |
| 14 | Leukotriene A4 (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. | — | 300 |
About the Interleukin-18 signaling Pathway
The Interleukin-18 signaling pathway is catalogued in Reactome (ID: R-HSA-9012546) and involves 1 genes. In the BiohacksAI corpus, 14 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX5.