RHOD GTPase cycle
REACTOME PATHWAYThe RHOD GTPase cycle pathway (Reactome ID: R-HSA-9013405) involves 8 genes and is affected by 17 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting RHOD GTPase cycle
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | kenpaullone | — | 8 |
| 2 | pictilisib | — | 25 |
| 3 | ly294002 | — | 11 |
| 4 | Sirolimus | — | 300 |
| 5 | Wortmannin | — | 300 |
| 6 | alpelisib | — | 227 |
| 7 | torin 1 | — | 10 |
| 8 | Quercetin | — | 300 |
| 9 | Pueraria | — | 300 |
| 10 | Kaempferols | — | 300 |
| 11 | Catechin | — | 300 |
| 12 | Equilin | — | 216 |
| 13 | Hydrocortisone | — | 299 |
| 14 | Hydrocortisone | — | 298 |
| 15 | alsterpaullone | — | 12 |
| 16 | Guanosine Diphosphate | — | 300 |
| 17 | Guanosine Triphosphate Guanosine 5'-(tetrahydrogen triphosphate). | — | 300 |
About the RHOD GTPase cycle Pathway
The RHOD GTPase cycle pathway is catalogued in Reactome (ID: R-HSA-9013405) and involves 8 genes. In the BiohacksAI corpus, 17 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARHGAP35, BUB1B-PAK6, PAK5, PAK6, PIK3R1.