RHOBTB1 GTPase cycle
REACTOME PATHWAYThe RHOBTB1 GTPase cycle pathway (Reactome ID: R-HSA-9013422) involves 3 genes and is affected by 11 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting RHOBTB1 GTPase cycle
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | hydroxyfasudil [Supplementary Concept] | — | 11 |
| 2 | kenpaullone | — | 8 |
| 3 | Kinetin | — | 300 |
| 4 | alsterpaullone | — | 12 |
| 5 | Crizotinib | — | 298 |
| 6 | Edaravone | — | 298 |
| 7 | sp600125 | — | 117 |
| 8 | Sildenafil Citrate | — | 300 |
| 9 | Epimedium | — | 300 |
| 10 | Papaverine | — | 299 |
| 11 | Methylene Blue | — | 200 |
About the RHOBTB1 GTPase cycle Pathway
The RHOBTB1 GTPase cycle pathway is catalogued in Reactome (ID: R-HSA-9013422) and involves 3 genes. In the BiohacksAI corpus, 11 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCT2, PDE5A, ROCK2.