RHOV GTPase cycle
REACTOME PATHWAYThe RHOV GTPase cycle pathway (Reactome ID: R-HSA-9013424) involves 7 genes and is affected by 15 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting RHOV GTPase cycle
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | kenpaullone | — | 8 |
| 2 | pictilisib | — | 25 |
| 3 | Wortmannin | — | 300 |
| 4 | ly294002 | — | 11 |
| 5 | alpelisib | — | 227 |
| 6 | Sirolimus | — | 300 |
| 7 | torin 1 | — | 10 |
| 8 | Quercetin | — | 300 |
| 9 | alsterpaullone | — | 12 |
| 10 | Axitinib | — | 298 |
| 11 | Sorafenib | — | 300 |
| 12 | Dasatinib | — | 299 |
| 13 | Crizotinib | — | 298 |
| 14 | casin | — | 10 |
| 15 | Ergosterol | — | 300 |
About the RHOV GTPase cycle Pathway
The RHOV GTPase cycle pathway is catalogued in Reactome (ID: R-HSA-9013424) and involves 7 genes. In the BiohacksAI corpus, 15 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BUB1B-PAK6, CDC42, EPHA2, PAK4, PAK6.