Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives

Q: What compounds affect the Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives pathway?

59 compounds in the BiohacksAI corpus have documented interactions with genes in the Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives pathway (Reactome ID: R-HSA-9027604). These compounds target 2 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-90276042 genes59 compounds

The Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives pathway (Reactome ID: R-HSA-9027604) involves 2 genes and is affected by 59 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALOX5 PTGS2

Compounds Affecting Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives

#	Compound	Targets Hit	Studies
1	Celecoxib	—	295
2	Indomethacin	—	297
3	Resveratrol	—	298
4	pterostilbene	—	299
5	Quercetin	—	300
6	butein	—	158
7	ns398	—	116
8	Meloxicam	—	299
9	Naproxen	—	1,000
10	Etodolac	—	296
11	sulindac sulfide	—	79
12	Arachidonic Acid	—	245
13	aphs	—	7
14	Oxaprozin	—	181
15	sc560	—	13
16	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
17	cbd	—	298
18	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
19	Ursolic Acid	—	300
20	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
21	Acetylcysteine	—	298
22	Calcitriol	—	300
23	cannabidiol	—	296
24	Cephradine	—	298
25	Daunorubicin	—	298
26	Epinephrine	—	299
27	Ergotamine	—	299
28	Hesperidin	—	300
29	Indapamide	—	299
30	isoetharine	—	112
31	Lymecycline	—	143
32	Methyldopa	—	297
33	monorden	—	8
34	Niflumic Acid	—	300
35	Norepinephrine Precursor of epinephrine that is secreted by	—	298
36	Noscapine	—	300
37	Oxymetazoline	—	298
38	Oxymetholone	—	298
39	Phenylbutazone	—	300
40	Procarbazine	—	299
41	Rifaximin	—	298
42	Rolitetracycline	—	166
43	Sorafenib	—	300
44	Sulindac	—	297
45	Tigecycline	—	299
46	tiopronin	—	299
47	Tolmetin	—	298
48	Tripterygium	—	300
49	Troglitazone	—	299
50	trolox	—	300

About the Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives Pathway

The Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives pathway is catalogued in Reactome (ID: R-HSA-9027604) and involves 2 genes. In the BiohacksAI corpus, 59 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX5, PTGS2.