What compounds affect the Peroxisomal protein import pathway?

65 compounds in the BiohacksAI corpus have documented interactions with genes in the Peroxisomal protein import pathway (Reactome ID: R-HSA-9033241). These compounds target 8 genes within this pathway.

What genes are in the Peroxisomal protein import pathway?

The Peroxisomal protein import pathway involves 8 genes. Key genes include: ECH1, EPHX2, GSTK1, IDE, IDH1, NOS2, PAOX, PECR.

Peroxisomal protein import

REACTOME PATHWAY

Reactome: R-HSA-90332418 genes65 compounds

The Peroxisomal protein import pathway (Reactome ID: R-HSA-9033241) involves 8 genes and is affected by 65 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ECH1 EPHX2 GSTK1 IDE IDH1 NOS2 PAOX PECR

Compounds Affecting Peroxisomal protein import

#	Compound	Targets Hit	Studies
1	Chlorhexidine	—	299
2	licochalcone	—	267
3	Mometasone Furoate	—	292
4	Dinitrochlorobenzene	—	300
5	Lovastatin	—	300
6	Methylene Blue	—	200
7	Sertraline	—	1,000
8	Simvastatin	—	1,000
9	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
10	2-Chloroadenosine 2-Chloroadenosine.	—	300
11	6-Aminonicotinamide	—	300
12	Methotrexate	—	289
13	Anisomycin	—	247
14	Astemizole Antihistamine drug now withdrawn from	—	280
15	Azacitidine	—	298
16	Azacitidine	—	300
17	Azathioprine	—	300
18	Calcimycin	—	216
19	Carbazilquinone	—	48
20	Ciclopirox	—	88
21	clofilium tosylate	—	4
22	colchine	—	2
23	cycloheximide	—	300
24	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
25	Digitoxin	—	300
26	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
27	Digoxin	—	299
28	Ethinyl Estradiol	—	300
29	Fluspirilene	—	74
30	Hexachlorophene	—	300
31	Imatinib Mesylate	—	300
32	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
33	Miconazole	—	298
34	Niclosamide	—	299
35	Nisoldipine	—	297
36	Nortriptyline	—	28
37	propionylpromazine hydrochloride	—	2
38	Quinestrol	—	194
39	Salmeterol Xinafoate	—	227
40	streptonigrin	—	299
41	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
42	Thioridazine	—	35
43	triflupromazine hydrochloride	—	12
44	Tubercidin	—	300
45	tyrphostin 9	—	2
46	vinblastine sulfate	—	81
47	Nitroarginine	—	300
48	Arginine	—	300
49	Arginine	—	300
50	NG-Nitroarginine Methyl Ester	—	238

About the Peroxisomal protein import Pathway

The Peroxisomal protein import pathway is catalogued in Reactome (ID: R-HSA-9033241) and involves 8 genes. In the BiohacksAI corpus, 65 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ECH1, EPHX2, GSTK1, IDE, IDH1.