Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
REACTOME PATHWAYThe Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) pathway (Reactome ID: R-HSA-936964) involves 3 genes and is affected by 5 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | amlexanox | — | 96 |
| 2 | Crizotinib | — | 298 |
| 3 | Axitinib | — | 298 |
| 4 | celastrol | — | 300 |
| 5 | Disulfiram | — | 297 |
About the Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Pathway
The Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) pathway is catalogued in Reactome (ID: R-HSA-936964) and involves 3 genes. In the BiohacksAI corpus, 5 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include IKBKE, SARM1, TBK1.