What genes are in the Negative regulation of NOTCH4 signaling pathway?

The Negative regulation of NOTCH4 signaling pathway involves 35 genes. Key genes include: ADRM1, CUL1, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1.

Negative regulation of NOTCH4 signaling

Q: What compounds affect the Negative regulation of NOTCH4 signaling pathway?

24 compounds in the BiohacksAI corpus have documented interactions with genes in the Negative regulation of NOTCH4 signaling pathway (Reactome ID: R-HSA-9604323). These compounds target 35 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-960432335 genes24 compounds

The Negative regulation of NOTCH4 signaling pathway (Reactome ID: R-HSA-9604323) involves 35 genes and is affected by 24 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CUL1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6+5 more

Compounds Affecting Negative regulation of NOTCH4 signaling

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
4	ninhydrin	—	300
5	Disulfiram	—	297
6	4-Hydroxybenzoate-3-Monooxygenase	—	300
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	chrysin	—	300
9	egcg	—	300
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
11	Quercetin	—	300
12	Genistein	—	300
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	Aminoimidazole Carboxamide	—	121
15	Histamine	—	300
16	cefaclor	—	299
17	Cefdinir	—	298
18	Oxytetracycline	—	300
19	streptonigrin	—	299
20	Thioridazine	—	35
21	candesartan cilexetil [Supplementary Concept]	—	300
22	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
23	Pioglitazone	—	297
24	Harmaline	—	300

About the Negative regulation of NOTCH4 signaling Pathway

The Negative regulation of NOTCH4 signaling pathway is catalogued in Reactome (ID: R-HSA-9604323) and involves 35 genes. In the BiohacksAI corpus, 24 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CUL1, PSMA1, PSMA2, PSMA3.