Negative regulation of NMDA receptor-mediated neuronal transmission
REACTOME PATHWAYThe Negative regulation of NMDA receptor-mediated neuronal transmission pathway (Reactome ID: R-HSA-9617324) involves 7 genes and is affected by 27 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Negative regulation of NMDA receptor-mediated neuronal transmission
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Glutamic Acid | — | 297 |
| 2 | Glutamic Acid | — | 300 |
| 3 | Glycine | — | 300 |
| 4 | pentamidine | — | 299 |
| 5 | Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of | — | 296 |
| 6 | Dextrorphan Dextro form of levorphanol. It acts as | — | 300 |
| 7 | Levorphanol | — | 297 |
| 8 | cycloserine | — | 298 |
| 9 | Aspartic Acid | — | 300 |
| 10 | D-Aspartic Acid | — | 29 |
| 11 | Ethidium | — | 300 |
| 12 | Dextrothyroxine | — | 134 |
| 13 | Dizocilpine Maleate | — | 300 |
| 14 | Ibotenic Acid | — | 300 |
| 15 | Spermine | — | 300 |
| 16 | eliprodil | — | 33 |
| 17 | Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as | — | 34 |
| 18 | sp600125 | — | 117 |
| 19 | KN 92 [Supplementary Concept] KN 93 isomer; | — | 26 |
| 20 | Kynurenic Acid | — | 300 |
| 21 | Phenformin | — | 300 |
| 22 | Carvedilol | — | 296 |
| 23 | Ibogaine | — | 300 |
| 24 | Quercetin | — | 300 |
| 25 | Sorafenib | — | 300 |
| 26 | alsterpaullone | — | 12 |
| 27 | pictilisib | — | 25 |
About the Negative regulation of NMDA receptor-mediated neuronal transmission Pathway
The Negative regulation of NMDA receptor-mediated neuronal transmission pathway is catalogued in Reactome (ID: R-HSA-9617324) and involves 7 genes. In the BiohacksAI corpus, 27 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CAMK1, CAMK2B, CAMK2D, GRIN1, GRIN2A.