What compounds affect the Long-term potentiation pathway?

39 compounds in the BiohacksAI corpus have documented interactions with genes in the Long-term potentiation pathway (Reactome ID: R-HSA-9620244). These compounds target 10 genes within this pathway.

What genes are in the Long-term potentiation pathway?

The Long-term potentiation pathway involves 10 genes. Key genes include: CAMK2B, CAMK2D, ERBB4, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, SRC.

Long-term potentiation

REACTOME PATHWAY

Reactome: R-HSA-962024410 genes39 compounds

The Long-term potentiation pathway (Reactome ID: R-HSA-9620244) involves 10 genes and is affected by 39 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CAMK2B CAMK2D ERBB4 GRIA1 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2C SRC

Compounds Affecting Long-term potentiation

#	Compound	Targets Hit	Studies
1	Glutamic Acid	—	297
2	Glutamic Acid	—	300
3	Glycine	—	300
4	pentamidine	—	299
5	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
6	Dextrorphan Dextro form of levorphanol. It acts as	—	300
7	Levorphanol	—	297
8	cycloserine	—	298
9	Aspartic Acid	—	300
10	D-Aspartic Acid	—	29
11	Ethidium	—	300
12	Dextrothyroxine	—	134
13	Dizocilpine Maleate	—	300
14	Ibotenic Acid	—	300
15	Spermine	—	300
16	eliprodil	—	33
17	Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as	—	34
18	sp600125	—	117
19	Dasatinib	—	299
20	tyrphostin ag 1478	—	4
21	Sorafenib	—	300
22	Quercetin	—	300
23	Afatinib	—	297
24	alsterpaullone	—	12
25	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	—	300
26	aniracetam	—	110
27	Piracetam	—	300
28	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
29	Kynurenic Acid	—	300
30	Phenformin	—	300
31	Carvedilol	—	296
32	Ibogaine	—	300
33	Resveratrol	—	298
34	Adenosine Monophosphate Adenine nucleotide containing	—	300
35	Crizotinib	—	298
36	kenpaullone	—	8
37	monorden	—	8
38	Niclosamide	—	299
39	Riluzole	—	298

About the Long-term potentiation Pathway

The Long-term potentiation pathway is catalogued in Reactome (ID: R-HSA-9620244) and involves 10 genes. In the BiohacksAI corpus, 39 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CAMK2B, CAMK2D, ERBB4, GRIA1, GRIA2.