Estrogen-stimulated signaling through PRKCZ
REACTOME PATHWAYThe Estrogen-stimulated signaling through PRKCZ pathway (Reactome ID: R-HSA-9634635) involves 3 genes and is affected by 25 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Estrogen-stimulated signaling through PRKCZ
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | alsterpaullone | — | 12 |
| 2 | kenpaullone | — | 8 |
| 3 | sp600125 | — | 117 |
| 4 | plumbagin [Supplementary Concept] | — | 300 |
| 5 | pd98059 | — | 7 |
| 6 | tyrphostin ag 1478 | — | 4 |
| 7 | Clotrimazole | — | 296 |
| 8 | fisetin | — | 78 |
| 9 | Progesterone | — | 299 |
| 10 | 2-Chloroadenosine 2-Chloroadenosine. | — | 300 |
| 11 | Benzalkonium Compounds | — | 299 |
| 12 | Calcimycin | — | 216 |
| 13 | daph | — | 2 |
| 14 | Diphenhydramine | — | 14 |
| 15 | ha1004 | — | 4 |
| 16 | isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from | — | 300 |
| 17 | Lithocholic Acid | — | 300 |
| 18 | Loratadine | — | 296 |
| 19 | Sorafenib | — | 300 |
| 20 | trametinib | — | 296 |
| 21 | trequinsin hydrochloride | — | 1 |
| 22 | withaferin | — | 300 |
| 23 | Arachidonic Acid | — | 245 |
| 24 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 25 | Sphingosine | — | 300 |
About the Estrogen-stimulated signaling through PRKCZ Pathway
The Estrogen-stimulated signaling through PRKCZ pathway is catalogued in Reactome (ID: R-HSA-9634635) and involves 3 genes. In the BiohacksAI corpus, 25 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include MAPK1, PDPK1, PRKCZ.