What compounds target MAPK1?

BiohacksAI has identified 176 compounds that interact with MAPK1 (mitogen-activated protein kinase 1). Top compounds include: tretinoin, seliciclib, caffeic acid phenethyl ester, benzbromarone, doramapimod. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is MAPK1 (mitogen-activated protein kinase)?

MAPK1 is mitogen-activated protein kinase 1. It is a molecular target for 176 compounds documented in PubMed bioassay data. UniProt ID: P28482. NCBI Gene ID: 5594.

MAPK1

MOLECULAR TARGET

mitogen-activated protein kinase 1

UniProt: P28482 NCBI Gene: 5594176 compounds

MAPK1 (mitogen-activated protein kinase 1) is targeted by 176 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting MAPK1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	tretinoin	5.16	174
2	seliciclib	4.91	135
3	caffeic acid phenethyl ester	4.25	69
4	benzbromarone	4.13	61
5	doramapimod	4.06	57
6	zafirlukast	3.89	48
7	olomoucine	3.71	40
8	isotretinoin	3.66	38
9	dicumarol	3.56	34
10	meclofenamic acid	3.50	32
11	tae 684	3.43	30
12	iodotubercidin	3.30	26
13	mirdametinib	3.18	23
14	pf 03758309	3.00	19
15	hymenialdisine	3.00	19
16	bithionol	2.89	17
17	pf 00562271	2.77	15
18	nalfurafine	2.77	15
19	6 benzylaminopurine	2.77	15
20	closantel	2.71	14
21	tivozanib	2.64	13
22	plumbagin [Supplementary Concept]	2.56	12
23	debromohymenialdisine	2.56	12
24	ulixertinib	2.56	12
25	bay 293	2.48	11
26	aceclofenac	2.48	11
27	aloisine a	2.40	10
28	exisulind	2.30	9
29	iodoquinol	2.20	8
30	sb 220025	2.20	8
31	ravoxertinib	2.08	7
32	pd98059	1.95	6
33	tanzisertib	1.95	6
34	tribromsalan	1.95	6
35	3345 tetrachlorosalicylanilide	1.95	6
36	tyrphostin ag 1478	1.79	5
37	alsterpaullone	1.39	3
38	kenpaullone	1.39	3
39	Clotrimazole	1.10	2
40	sp600125	1.10	2
41	achyranthes bidentata	1.00	1
42	agastache rugosa	1.00	1
43	Garlic	1.00	1
44	allium tuberosum	1.00	1
45	aloe vera	1.00	1
46	anemarrhena asphodeloides	1.00	1
47	apis mellifera	1.00	1
48	arctium lappa	1.00	1
49	Areca	1.00	1
50	artemisia argyi	1.00	1

Showing top 50 of 176 compounds. Use the BiohacksAI search to explore all MAPK1 modulators.

About MAPK1 as a Drug Target

MAPK1 (mitogen-activated protein kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 176 compounds with documented MAPK1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

MAPK1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.