Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
REACTOME PATHWAYThe Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) pathway (Reactome ID: R-HSA-9661069) involves 4 genes and is affected by 11 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | indirubin | — | 300 |
| 2 | alsterpaullone | — | 12 |
| 3 | kenpaullone | — | 8 |
| 4 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 5 | chrysin | — | 300 |
| 6 | fisetin | — | 78 |
| 7 | Sorafenib | — | 300 |
| 8 | Aurintricarboxylic Acid | — | 184 |
| 9 | Methylergonovine | — | 14 |
| 10 | sp600125 | — | 117 |
| 11 | Adenosine Triphosphate | — | 300 |
About the Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Pathway
The Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) pathway is catalogued in Reactome (ID: R-HSA-9661069) and involves 4 genes. In the BiohacksAI corpus, 11 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNE2, CDK2, CDK4, CDK6.