Transcriptional regulation of testis differentiation
REACTOME PATHWAYThe Transcriptional regulation of testis differentiation pathway (Reactome ID: R-HSA-9690406) involves 1 genes and is affected by 27 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Transcriptional regulation of testis differentiation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Cladribine | — | 297 |
| 2 | vinblastine sulfate | — | 81 |
| 3 | Progesterone | — | 299 |
| 4 | Gemfibrozil | — | 297 |
| 5 | Podophyllotoxin | — | 14 |
| 6 | Triiodothyronine | — | 300 |
| 7 | Methylene Blue | — | 200 |
| 8 | Resveratrol | — | 298 |
| 9 | Aldosterone | — | 300 |
| 10 | Methotrexate | — | 289 |
| 11 | Anisomycin | — | 247 |
| 12 | Azacitidine | — | 298 |
| 13 | Azacitidine | — | 300 |
| 14 | Bromodeoxyuridine | — | 300 |
| 15 | calycosin | — | 300 |
| 16 | Cilostazol | — | 297 |
| 17 | clofilium tosylate | — | 4 |
| 18 | cycloheximide | — | 300 |
| 19 | Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide. | — | 300 |
| 20 | Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide. | — | 300 |
| 21 | Digoxin | — | 299 |
| 22 | dihydrorotenone | — | 13 |
| 23 | Ethidium | — | 300 |
| 24 | Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale, | — | 115 |
| 25 | Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide. | — | 300 |
| 26 | Tubercidin | — | 300 |
| 27 | tyrphostin 9 | — | 2 |
About the Transcriptional regulation of testis differentiation Pathway
The Transcriptional regulation of testis differentiation pathway is catalogued in Reactome (ID: R-HSA-9690406) and involves 1 genes. In the BiohacksAI corpus, 27 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include NR5A1.