IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
REACTOME PATHWAYThe IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway (Reactome ID: R-HSA-975144) involves 4 genes and is affected by 18 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Crizotinib | — | 298 |
| 2 | alsterpaullone | — | 12 |
| 3 | chicoric acid | — | 117 |
| 4 | naringin | — | 300 |
| 5 | Chlorhexidine | — | 299 |
| 6 | Perphenazine | — | 297 |
| 7 | Sphingosine | — | 300 |
| 8 | Resveratrol | — | 298 |
| 9 | Sertraline | — | 1,000 |
| 10 | Astemizole Antihistamine drug now withdrawn from | — | 280 |
| 11 | Canrenone | — | 300 |
| 12 | Thioridazine | — | 35 |
| 13 | Afatinib | — | 297 |
| 14 | Axitinib | — | 298 |
| 15 | Sorafenib | — | 300 |
| 16 | Aurintricarboxylic Acid | — | 184 |
| 17 | sp600125 | — | 117 |
| 18 | glaucarubinone | — | 10 |
About the IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Pathway
The IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway is catalogued in Reactome (ID: R-HSA-975144) and involves 4 genes. In the BiohacksAI corpus, 18 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CHUK, IKBKB, IRAK1, UBE2N.