What compounds affect the Formation of intermediate mesoderm pathway?

26 compounds in the BiohacksAI corpus have documented interactions with genes in the Formation of intermediate mesoderm pathway (Reactome ID: R-HSA-9761174). These compounds target 1 genes within this pathway.

What genes are in the Formation of intermediate mesoderm pathway?

The Formation of intermediate mesoderm pathway involves 1 genes. Key genes include: PAX8.

Formation of intermediate mesoderm

REACTOME PATHWAY

Reactome: R-HSA-97611741 genes26 compounds

The Formation of intermediate mesoderm pathway (Reactome ID: R-HSA-9761174) involves 1 genes and is affected by 26 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

PAX8

Compounds Affecting Formation of intermediate mesoderm

#	Compound	Targets Hit	Studies
1	Chlorhexidine	—	299
2	Demecolcine	—	246
3	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
4	Anisomycin	—	247
5	Colchicine	—	300
6	colchine	—	2
7	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
8	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
9	Digoxin	—	299
10	Hexachlorophene	—	300
11	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
12	Podophyllotoxin	—	14
13	vinblastine sulfate	—	81
14	Vorinostat	—	299
15	2-Chloroadenosine 2-Chloroadenosine.	—	300
16	Astemizole Antihistamine drug now withdrawn from	—	280
17	Calcimycin	—	216
18	Ciclopirox	—	88
19	clofilium tosylate	—	4
20	Decitabine	—	298
21	Ethidium	—	300
22	gedunin	—	54
23	mg624	—	3
24	Nocodazole Nocodazole is	—	215
25	torin 1	—	10
26	tyrphostin 9	—	2

About the Formation of intermediate mesoderm Pathway

The Formation of intermediate mesoderm pathway is catalogued in Reactome (ID: R-HSA-9761174) and involves 1 genes. In the BiohacksAI corpus, 26 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PAX8.