Formation of WDR5-containing histone-modifying complexes

Q: What compounds affect the Formation of WDR5-containing histone-modifying complexes pathway?

41 compounds in the BiohacksAI corpus have documented interactions with genes in the Formation of WDR5-containing histone-modifying complexes pathway (Reactome ID: R-HSA-9772755). These compounds target 9 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-97727559 genes41 compounds

The Formation of WDR5-containing histone-modifying complexes pathway (Reactome ID: R-HSA-9772755) involves 9 genes and is affected by 41 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ASH2L DPY30 KAT2A KAT2B KMT2A MEN1 PSIP1 RBBP5 WDR5

Compounds Affecting Formation of WDR5-containing histone-modifying complexes

#	Compound	Targets Hit	Studies
1	s adenosylhomocysteine	—	300
2	Aurintricarboxylic Acid	—	184
3	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
4	Nitroblue Tetrazolium Colorless to yellow dye that is reducible to blue or black formazan crystals by certain cells; formerly used to distinguish between nonbacterial and bacterial diseases,	—	300
5	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
6	DEAD-box RNA Helicases	—	169
7	Thioctic Acid	—	298
8	Arachidonic Acid	—	245
9	Oleic Acid	—	112
10	alpha-Linolenic Acid	—	300
11	candesartan cilexetil [Supplementary Concept]	—	300
12	Cisplatin	—	300
13	diallyl trisulfide	—	246
14	Estramustine	—	300
15	gamma-Linolenic Acid	—	300
16	Hexachlorophene	—	300
17	Iodoacetamide	—	300
18	Lithocholic Acid	—	300
19	Oxytetracycline	—	300
20	rafoxanide	—	172
21	Ritonavir	—	298
22	Thioctic Acid	—	300
23	Trazodone	—	297
24	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
25	Cefixime	—	300
26	Levodopa	—	297
27	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
28	Methylene Blue	—	200
29	Biotin	—	297
30	Ethidium	—	300
31	furylfuramide	—	82
32	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
33	Demeclocycline	—	5
34	Edaravone	—	298
35	Methyldopa	—	297
36	alphitonin [Supplementary Concept] from	—	300
37	scutellarein	—	113
38	Suramin	—	300
39	np1	—	81
40	egcg	—	300
41	plumbagin [Supplementary Concept]	—	300

About the Formation of WDR5-containing histone-modifying complexes Pathway

The Formation of WDR5-containing histone-modifying complexes pathway is catalogued in Reactome (ID: R-HSA-9772755) and involves 9 genes. In the BiohacksAI corpus, 41 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ASH2L, DPY30, KAT2A, KAT2B, KMT2A.