What compounds affect the Formation of the nephric duct pathway?

36 compounds in the BiohacksAI corpus have documented interactions with genes in the Formation of the nephric duct pathway (Reactome ID: R-HSA-9830364). These compounds target 3 genes within this pathway.

What genes are in the Formation of the nephric duct pathway?

The Formation of the nephric duct pathway involves 3 genes. Key genes include: ID4, PAX8, RET.

Formation of the nephric duct

REACTOME PATHWAY

Reactome: R-HSA-98303643 genes36 compounds

The Formation of the nephric duct pathway (Reactome ID: R-HSA-9830364) involves 3 genes and is affected by 36 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ID4 PAX8 RET

Compounds Affecting Formation of the nephric duct

#	Compound	Targets Hit	Studies
1	Chlorhexidine	—	299
2	Demecolcine	—	246
3	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
4	Anisomycin	—	247
5	Colchicine	—	300
6	colchine	—	2
7	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
8	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
9	Digoxin	—	299
10	Hexachlorophene	—	300
11	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
12	Podophyllotoxin	—	14
13	vinblastine sulfate	—	81
14	Vorinostat	—	299
15	2-Chloroadenosine 2-Chloroadenosine.	—	300
16	Astemizole Antihistamine drug now withdrawn from	—	280
17	Calcimycin	—	216
18	Ciclopirox	—	88
19	clofilium tosylate	—	4
20	Decitabine	—	298
21	Ethidium	—	300
22	gedunin	—	54
23	mg624	—	3
24	Nocodazole Nocodazole is	—	215
25	torin 1	—	10
26	tyrphostin 9	—	2
27	Sorafenib	—	300
28	Axitinib	—	298
29	Dasatinib	—	299
30	Crizotinib	—	298
31	Nortriptyline	—	295
32	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
33	sp600125	—	117
34	alpha-Linolenic Acid	—	300
35	Dehydrocholic Acid	—	203
36	Practolol	—	300

About the Formation of the nephric duct Pathway

The Formation of the nephric duct pathway is catalogued in Reactome (ID: R-HSA-9830364) and involves 3 genes. In the BiohacksAI corpus, 36 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ID4, PAX8, RET.