Co-stimulation by ICOS
REACTOME PATHWAYThe Co-stimulation by ICOS pathway (Reactome ID: R-HSA-9927354) involves 7 genes and is affected by 10 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Co-stimulation by ICOS
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sirolimus | — | 300 |
| 2 | ly294002 | — | 11 |
| 3 | pictilisib | — | 25 |
| 4 | Wortmannin | — | 300 |
| 5 | alpelisib | — | 227 |
| 6 | torin 1 | — | 10 |
| 7 | Quercetin | — | 300 |
| 8 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 9 | Ku 0063794 [Supplementary Concept] | — | 7 |
| 10 | Resveratrol | — | 298 |
About the Co-stimulation by ICOS Pathway
The Co-stimulation by ICOS pathway is catalogued in Reactome (ID: R-HSA-9927354) and involves 7 genes. In the BiohacksAI corpus, 10 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2.