Question 1

What compounds affect the The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex pathway?

Accepted Answer

17 compounds in the BiohacksAI corpus have documented interactions with genes in the The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex pathway (Reactome ID: R-HSA-9931521). These compounds target 4 genes within this pathway.

Question 2

What genes are in the The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex pathway?

Accepted Answer

The The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex pathway involves 4 genes. Key genes include: CREBBP, CSNK1D, CSNK1E, KMT2A.

#	Compound	Targets Hit	Studies
1	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
2	pictilisib	—	25
3	sp600125	—	117
4	egcg	—	300
5	Afatinib	—	297
6	Dasatinib	—	299
7	s adenosylhomocysteine	—	300
8	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
9	Aurintricarboxylic Acid	—	184
10	Nitroblue Tetrazolium Colorless to yellow dye that is reducible to blue or black formazan crystals by certain cells; formerly used to distinguish between nonbacterial and bacterial diseases,	—	300
11	scutellarein	—	113
12	Suramin	—	300
13	alsterpaullone	—	12
14	Papaverine	—	299
15	Colchicine	—	300
16	Etazolate	—	66
17	Nocodazole Nocodazole is	—	215

BiohacksAI

The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex

Genes in this Pathway

Compounds Affecting The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex

About the The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Pathway