What compounds target ADORA2A?

BiohacksAI has identified 48 compounds that interact with ADORA2A (adenosine A2a receptor). Top compounds include: tamoxifen, nifedipine, allopurinol, sb 203580, neca. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ADORA2A (adenosine A2a receptor)?

ADORA2A is adenosine A2a receptor. It is a molecular target for 48 compounds documented in PubMed bioassay data. UniProt ID: P30543. NCBI Gene ID: 25369.

ADORA2A

MOLECULAR TARGET

adenosine A2a receptor

UniProt: P30543 NCBI Gene: 2536948 compounds

ADORA2A (adenosine A2a receptor) is targeted by 48 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ADORA2A

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	tamoxifen	5.88	358
2	nifedipine	5.34	208
3	allopurinol	5.04	154
4	sb 203580	4.92	136
5	neca	4.86	128
6	sildenafil	4.78	118
7	raloxifene	4.77	117
8	13 dipropyl 8 cyclopentylxanthine dpcpx	4.57	96
9	galangin	4.30	73
10	n6 cyclopentyladenosine	4.28	71
11	sr mefloquine	4.28	71
12	diethylstilbestrol	4.06	57
13	gentian violet	4.03	55
14	ib meca	4.01	54
15	amiloride	3.95	51
16	namodenoson	3.95	51
17	zm 241385	3.87	47
18	cgs 21680	3.66	38
19	s dhpa	3.64	37
20	istradefylline	3.50	32
21	cgs 15943	3.47	31
22	r pia	3.47	31
23	sch 58261	3.40	29
24	xanthine amine congener	3.37	28
25	8 phenyl theophylline	3.26	25
26	imiquimod	3.14	22
27	enprofylline	2.94	18
28	2-Chloroadenosine 2-Chloroadenosine.	2.89	17
29	bithionol	2.89	17
30	psilocin	2.77	15
31	rolofylline	2.71	14
32	nn hexamethyleneamiloride	2.56	12
33	defactinib	2.48	11
34	gsk046	2.40	10
35	s pia	2.40	10
36	trioxsalen	2.30	9
37	Adenosine	2.20	8
38	regadenoson anhydrous	2.20	8
39	metrifudil	2.20	8
40	tozadenant	2.08	7
41	ciforadenant	1.95	6
42	tecadenoson	1.95	6
43	Caffeine	1.79	5
44	rs mefloquine	1.79	5
45	st1535	1.79	5
46	binodenoson	1.79	5
47	Apigenin 5,7,4'-trihydroxy-flavone,	0.69	1
48	Quercetin	0.69	1

About ADORA2A as a Drug Target

ADORA2A (adenosine A2a receptor) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 48 compounds with documented ADORA2A interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ADORA2A inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.