What compounds target CLK4?

BiohacksAI has identified 47 compounds that interact with CLK4 (CDC like kinase 4). Top compounds include: imatinib, epigalocatechin gallate, seliciclib, foretinib, ruxolitinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CLK4 (CDC like kinase)?

CLK4 is CDC like kinase 4. It is a molecular target for 47 compounds documented in PubMed bioassay data. UniProt ID: Q9HAZ1. NCBI Gene ID: 57396.

CLK4

MOLECULAR TARGET

CDC like kinase 4

UniProt: Q9HAZ1 NCBI Gene: 5739647 compounds

CLK4 (CDC like kinase 4) is targeted by 47 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CLK4

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	imatinib	5.47	236
2	epigalocatechin gallate	5.40	220
3	seliciclib	4.91	135
4	foretinib	4.34	76
5	ruxolitinib	4.23	68
6	nilotinib	4.17	64
7	bosutinib	4.08	58
8	midostaurin	3.85	46
9	silmitasertib	3.78	43
10	abemaciclib	3.66	38
11	nintedanib	3.61	36
12	pelitinib	3.50	32
13	bms 387032	3.47	31
14	tae 684	3.43	30
15	fedratinib	3.40	29
16	linifanib	3.33	27
17	at 7519	3.33	27
18	tandutinib	3.22	24
19	sp 600125	3.22	24
20	dovitinib	3.09	21
21	jnj 7706621	3.09	21
22	lestaurtinib	3.04	20
23	pf 03758309	3.00	19
24	ruboxistaurin	2.94	18
25	r 406	2.83	16
26	k 252a	2.83	16
27	milciclib	2.77	15
28	capivasertib	2.77	15
29	kw 2449	2.64	13
30	mli 2	2.64	13
31	ast 487	2.56	12
32	su 014813	2.20	8
33	rebastinib	2.20	8
34	leucettamine b	2.20	8
35	enzastaurin	2.08	7
36	tg100 115	2.08	7
37	rg 547	2.08	7
38	tomivosertib	2.08	7
39	sel 120 free base	1.95	6
40	demethylbellidifolin	1.95	6
41	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	1.79	5
42	t3 clk	1.79	5
43	lorecivivint	1.79	5
44	hydroxyfasudil [Supplementary Concept]	1.10	2
45	pictilisib	1.10	2
46	sp600125	1.10	2
47	egcg	0.69	1

About CLK4 as a Drug Target

CLK4 (CDC like kinase 4) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 47 compounds with documented CLK4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CLK4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.