What compounds target DYRK1B?

BiohacksAI has identified 31 compounds that interact with DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B). Top compounds include: epigalocatechin gallate, seliciclib, alvocidib, pi 103, midostaurin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is DYRK1B (dual specificity tyrosine)?

DYRK1B is dual specificity tyrosine phosphorylation regulated kinase 1B. It is a molecular target for 31 compounds documented in PubMed bioassay data. UniProt ID: Q9Y463. NCBI Gene ID: 9149.

DYRK1B

MOLECULAR TARGET

dual specificity tyrosine phosphorylation regulated kinase 1B

UniProt: Q9Y463 NCBI Gene: 914931 compounds

DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B) is targeted by 31 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting DYRK1B

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	epigalocatechin gallate	5.40	220
2	seliciclib	4.91	135
3	alvocidib	4.52	91
4	pi 103	4.17	64
5	midostaurin	3.85	46
6	silmitasertib	3.78	43
7	abemaciclib	3.66	38
8	nintedanib	3.61	36
9	rucaparib	3.58	35
10	pelitinib	3.50	32
11	bms 387032	3.47	31
12	tae 684	3.43	30
13	fedratinib	3.40	29
14	at 7519	3.33	27
15	niraparib	3.30	26
16	lestaurtinib	3.04	20
17	ruboxistaurin	2.94	18
18	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	2.83	16
19	kw 2449	2.64	13
20	sgx 523	2.30	9
21	su 014813	2.20	8
22	leucettamine b	2.20	8
23	enzastaurin	2.08	7
24	tg100 115	2.08	7
25	rg 547	2.08	7
26	demethylbellidifolin	1.95	6
27	t3 clk	1.79	5
28	lorecivivint	1.79	5
29	egcg	0.69	1
30	Afatinib	0.69	1
31	pictilisib	0.69	1

About DYRK1B as a Drug Target

DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 31 compounds with documented DYRK1B interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

DYRK1B inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.